DaMBIC

Welcome to the Danish Molecular Biomedical Imaging Center (DaMBIC), a bioimaging core facility at the University of Southern Denmark, Odense, Denmark. 

The DaMBIC core facility provides access to state-of-the-art microscopy equipment, training and assistance required for the whole range of light microscopy for imaging specimens ranging from single molecules to cells, tissue and small animals. Exemplary case studies:

• Bioimaging:
  • Automated image acquisition and analysis 
  • Widefield and confocal immunofluorescence  
  • Co-localization studies 
  • Calcium ions and pH measurements in tissue and cells 
• Spatial Transcriptomics:
  • MERFISH (Multiplexed error-robust fluorescence in-situ hybridization) 
  • 10X Visium Spatial Gene Expression slides 
• Live Cell/Tissue imaging: 
  • Cell tracking in 2D and 3D 
  • Diffusion measurements in tissue 
  • Transport measurements in cells and membranes 
  • Multi-photon imaging of resistance arteries
  • Multi-photon of small animals 
• Super-resolution:
  • Super-resolution of tight junction proteins
  • Drug delivery systems 
  • MinFLUX imaging with a resolution of 2 nm
• Raman Based Label Free Imaging:  
  • Drug delivery 
  • Cancer diagnostics 
  • Food analysis 
  • Nano/micro plastics 

DaMBIC offers a range of imaging equipment ranging from automated widefield microscopes to advanced confocal and multiphoton microscopes, to an array of state of the art super resolution techniques and Raman based label free imaging techniques. A full list of the equipment can be seen here.  

Additionally, we provide support for experimental design and sample preparation, access to image analysis software and expertise in data analysis and microscopy education. 

PhD students, postdoctoral researcher, scientific staff and external academic and industry affiliated users may access our microscopes after a training by the DaMBIC staff. For more information see here.  

About DaMBIC 

DaMBIC's mission is to provide an open-access national bioimaging infrastructure. The facility provides cutting-edge bioimaging infrastructure and services at SDU, serving research groups across the faculties of Health Sciences (SUND), Engineering (TEK), and Natural Sciences (NAT). Additionally, DaMBIC extends its services to users from other Danish universities, as well as to international collaborators and companies. 

Thanks to a dedicated bioimaging research environment, expert personal and national and international collaborations, DaMBIC offers the ideal environment for a national Bioimaging infrastructure which will support high level research as well as education and training. This has been recognized by DaMBIC becoming a node in Euro-BioImaging and a Nikon Center of Excellence, underscoring its expertise and the quality of the facility.  

The Danish Molecular Biomedical Imaging Center (DaMBIC) operates under the leadership of Scientific Director Jonathan Brewer. It is further supported by the board of SDUimaging, which constitutes the steering committee. This structure supports a focused and strategic approach to advancing the center's objectives in molecular biomedical imaging at SDU. 

DaMBIC is funded by infrastructure grants from the Danish Ministry of Science, which include collaborations with other national research infrastructures including DBN, CellX and NanoCHEM. DaMBIC is also funded by grants from the Novo Nordisk foundation and the Carlsberg foundation. 

The daily operations of DaMBIC are administrated by Center Manager Morten Frendø Ebbesen, Imaging Specialist Anup Shrestha and Biomedical Laboratory Scientist Ulla Melchior Hansen. 

Nikon Center of Excellence

The Danish Molecular Biomedical Imaging Center (DaMBIC) at the University of Southern Denmark has been established to provide the infrastructure, instruments and expertise necessary for researchers to efficiently perform advanced light microscopy imaging projects.

DaMBIC has partnered with Nikon Instruments to establish a Nikon Center of Excellence at SDU in Odense. Nikon Centers of Excellence are state-of-the-art imaging facilities established as a partnership between the host institution and Nikon with the mission to:

• Promote innovation across a broad range of biological research fields by providing access to cutting edge microscopy and imaging equipment.
• Provide training in both basic and advanced light microscopy techniques.
• Serve as a learning hub for both scientists, as well as corporate partners and contributors.
• Develop new microscope setups and imaging techniques in dialogue with our users.
   

Nikon Imaging Centers
Nikon has developed a group of world leading imaging centers in order to provide researchers with the latest in cutting edge technology for imaging and microscopy. The DaMBIC is one of Nikons's global centers of excellence that provides researchers at academic institutions with access to the most advanced technology and optimum conditions for their ground-breaking scientific research.

Nikon Imaging Centers around the World